Hi, my name is
I am an innovation fellow at Cornell Tech and Technion
I hold a PhD in Biophysics
I produced 5 papers, 2 of which have already been published
Observing the Mushroom-to-Brush Transition for Kinesin Proteins
Published in Langmuir, 2013
ELP Dumont, H Belmas, and H Hess
The height of polymers grafted to a surface is predicted to be constant at low densities (“mushroom” regime) and increase with the third root of the polymer surface density at high densities (“brush” regime). This mushroom-to-brush transition is explored with kinesin-1 proteins adhered to a surface at controlled densities. The kinesin height is measured by attaching fluorescently labeled microtubules to the kinesins and determining their elevation using fluorescence interference contrast microscopy. Our measurements are consistent with a mushroom regime and a brush regime and a transition near the theoretically predicted density. The mushroom-to-brush transition may play a role in protein behavior in crowded cellular environments and may be exploited as a signal in intracellular regulation and mechanotransduction.
Fatigue Failure and Molecular Machine Design
Published in Small, 2011
ELP Dumont and H Hess
Sophisticated molecular machines have evolved in nature, and the first synthetic molecular machines have been demonstrated. With our increasing understanding of individual operating cycles, the question of how operation can be sustained over many cycles comes to the forefront. In the design of macroscale machines, performance and lifetime are opposing goals. Similarly, the natural evolution of biological nanomachines, such as myosin motor proteins, is likely constrained by lifetime requirements. Rather than bond rupture at high forces, bond fatigue under repeated small stresses may limit the mechanical performance of molecular machines. Here, the effect of cyclic stresses using single and double bonds as simple examples are discussed. Additionally, it is demonstrated that an increase in lifetime requires a reduction in mechanical load and that molecular engineering design features, such as polyvalent bonds capable of rebinding, can extend the bond lifetime dramatically. A universal scaling law for the force output of motors is extrapolated to the molecular scale to estimate the design space for molecular machines.
science is not different from art
so, I also make art
My work was exhibited at the Venice Biennale
I did a TED TALK
Because it's cool to have one.
Columbia University, 2012
and fun side projects
Luxury Hotel in Brazil
Cancer and nanoparticles
Oil drilling in China
French Daycars for toddlers
Management of the 400 public daycars
Bring out the tiger in you
PhD in biophysics, 2009-2013
Proteins at interfaces: Conformational change and wear
Mines de Paris
MS in Applied Physics, 2004-2007
French "Grande Ecole". Top 1%.
That's it for now
you're awesome, let's talk